Document Detail

Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.
MedLine Citation:
PMID:  23032367     Owner:  NLM     Status:  MEDLINE    
A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for effective targeted therapies. This review will highlight the role of the WNT, Notch, BMP and Hedgehog pathways in colon cancer.
Fred E Bertrand; C William Angus; William J Partis; George Sigounas
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-03
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-17     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4344-51     Citation Subset:  IM    
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MeSH Terms
Bone Morphogenetic Proteins / metabolism*
Colonic Neoplasms / metabolism*,  pathology
Hedgehog Proteins / metabolism*
Oncogene Proteins / metabolism
Receptors, Notch / metabolism*
Signal Transduction
Trans-Activators / metabolism
Wnt Proteins / antagonists & inhibitors,  metabolism*
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Gli protein; 0/Hedgehog Proteins; 0/Oncogene Proteins; 0/Receptors, Notch; 0/Trans-Activators; 0/Wnt Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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