| Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch. | |
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MedLine Citation:
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PMID: 23032367 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for effective targeted therapies. This review will highlight the role of the WNT, Notch, BMP and Hedgehog pathways in colon cancer. |
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Authors:
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Fred E Bertrand; C William Angus; William J Partis; George Sigounas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-03 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 11 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Cancer Biology; Department of Oncology; Brody School of Medicine at East Carolina University; Greenville, NC USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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