Document Detail

Developmental parameters of cell death in the wing disc of Drosophila.
MedLine Citation:
PMID:  9159134     Owner:  NLM     Status:  MEDLINE    
Apoptotic cell death in wing imaginal discs takes place in single cells or small clusters of neighboring cells. These cells are distributed throughout the anlage at early stages and in recognizable territories at late larval and pupal stages. Apoptotic cells remain in the epithelium 2-4 h, prior to being engulfed in place by hemolymph cells. Experimentally induced apoptosis in single cells or territories is accompanied by nonautonomous death of adjacent cells and of cells further away in adjacent territories. These effects are followed by changes in cell proliferation in both territories. Apogenetic mosaics in mutant discs show cell death throughout the anlage. Apoptosis provides a mechanism, in addition to cell proliferation control, for matching territories with different positional values or different genetic specifications.
M Milán; S Campuzano; A García-Bellido
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  94     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5691-6     Citation Subset:  IM    
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autonoma de Madrid, Cantoblanco 28049 Madrid, Spain.
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MeSH Terms
Cell Division
DNA / biosynthesis
Drosophila / genetics,  growth & development*
Genes, Reporter
In Situ Hybridization
Models, Biological
Wing / cytology,  growth & development
Reg. No./Substance:

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