Document Detail


Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity.
MedLine Citation:
PMID:  18230895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity and its sequelae may prove to be the greatest threat to human lifestyle and health in the developed world this century. The so called obesity epidemic has seen the incidence of obesity and overweight almost double in Western societies and the trend is mirrored in nations that are transitioning to first world economies. There is no doubt that much of the rise in obesity can be attributed to lifestyle factors such as the excess consumption of energy-dense foods and the decline in physical activity. However, the 'fetal origins'hypothesis, first proposed by Barker and colleagues and elaborated by several groups over the past 15 years to be termed the 'Developmental Origins of Adult Health and Disease' (DOHaD), provides an alternative explanation for the rising rates of obesity. The DOHaD hypothesis states that exposure to an unfavourable environment during development (either in utero or in the early postnatal period) programmes changes in fetal or neonatal development such that the individual is then at greater risk of developing adulthood disease. This chapter discusses the effects of maternal obesity on fetal development and birth outcomes as well as the manner in which DOHaD may contribute to the obesity epidemic.
Authors:
James Andrew Armitage; Lucilla Poston; Paul David Taylor
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Frontiers of hormone research     Volume:  36     ISSN:  0301-3073     ISO Abbreviation:  Front Horm Res     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-05-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0320246     Medline TA:  Front Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  73-84     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia. james.armitage@med.monash.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 2 / etiology
Diabetes, Gestational
Dietary Fats / administration & dosage
Female
Humans
Maternal Nutritional Physiological Phenomena*
Metabolic Syndrome X / etiology*
Obesity / complications,  etiology*
Pregnancy
Pregnancy Complications*
Pregnancy Outcome
Chemical
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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