| Developmental origins of the metabolic syndrome: Body clocks and stress responses. | |
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MedLine Citation:
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PMID: 20851177 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The prevalence of the metabolic syndrome, which represents a spectrum of metabolic and cardiovascular disorders, continues to increase at an alarming rate in contemporary society. Inadequate responses of an individual to environmental challenges such as unbalanced diet or lack of physical exercise during their life course has been recognised to increase risk of this pathological condition. Recent evidence suggests that this may involve alterations in the settings of the circadian clock system, which consists of oscillating molecular pacemakers found not only in the hypothalamic region of the brain but also in most peripheral tissues, and of the hypothalamic-pituitary-adrenal (HPA) axis which regulates stress responses. These two systems are now known to interact to produce an integrated response to environmental challenges. In this review, we highlight the importance of environmental cues during early development in establishing the homeostatic set-points of the circadian clock and HPA stress systems. These effects can operate within the normal range and are not in themselves pathological, but can nevertheless affect an individual's response to environmental challenges in adult life and thus their risk of the metabolic syndrome. |
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Authors:
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Felino R Cagampang; Kirsten R Poore; Mark A Hanson |
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Publication Detail:
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Type: Journal Article Date: 2010-09-17 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 25 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 214-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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