Document Detail

Developmental origins of disease paradigm: a mechanistic and evolutionary perspective.
MedLine Citation:
PMID:  15240866     Owner:  NLM     Status:  MEDLINE    
Fetal growth is determined by the interaction between the environment and the fetal genome. The fetal environment, in turn, is determined by the maternal environment and by maternal and placental physiology. There is evidence that the interaction between the fetal environment and genome can determine the risk of postnatal disease, as well as the individual's capacity to cope with the postnatal environment. Furthermore, the role of various forms of maternal constraint of fetal growth in determining the persistence of these responses is reviewed. A limited number of biologic processes can contribute to the mechanistic basis of these phenomena. In addition to immediate homeostatic responses, the developing organism may make predictive adaptive responses of no immediate advantage but with long-term consequences. An evolutionary perspective is provided, as well as a review of possible biologic processes. The "developmental origins of disease" paradigm is a reflection of the persistence of such mechanisms in humans who now live in very different environments from those within which they evolved. The developmental origins paradigm and its underlying mechanistic and evolutionary basis have major implications for addressing the increasing burden of metabolic and cardiovascular disease.
Peter D Gluckman; Mark A Hanson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2004-07-07
Journal Detail:
Title:  Pediatric research     Volume:  56     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2005-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand.
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MeSH Terms
Birth Weight
Fetal Development*
Fetus* / anatomy & histology,  physiology
Maternal Exposure

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