Document Detail


Developmental origins of childhood overweight: potential public health impact.
MedLine Citation:
PMID:  18451768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several modifiable pre- and postnatal determinants of childhood overweight are known, but no one has examined how they influence risk of overweight in combination. We estimated the risk of overweight at age 3 years according to levels of maternal smoking during pregnancy, gestational weight gain, breastfeeding duration, and infant sleep duration. We studied 1,110 mother-child pairs in Project Viva, a prospective prebirth cohort study. The main outcome measure was child overweight (BMI for age and sex >or=95th percentile) at age 3. We ran logistic regression models with all four modifiable risk factors as well as the covariates maternal BMI and education, child race/ethnicity, and household income. From the model, we obtained the estimated probability of overweight for each of the 16 combinations of the four risk factors. During pregnancy, 9.8% of mothers smoked and 50% gained excessive weight. In infancy, 73% mother-child pairs breastfed for <12 m, and 31% of infants slept <12 h/day. Among the 3-year-old children in the cohort, 9.5% were overweight. In the prediction model, the estimated probability of overweight ranged from 0.06 among children exposed to favorable levels of all four risk factors, to 0.29 with adverse levels of all four. Healthful levels of four behaviors during early development predicted much lower probability of overweight at age 3 than adverse levels. Interventions to modify several factors during pregnancy and infancy could have substantial impact on prevention of childhood overweight.
Authors:
Matthew W Gillman; Sheryl L Rifas-Shiman; Ken Kleinman; Emily Oken; Janet W Rich-Edwards; Elsie M Taveras
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-05-01
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  16     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-12     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1651-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index*
Breast Feeding / adverse effects
Child Development*
Child, Preschool
Female
Humans
Logistic Models
Male
Massachusetts
Overweight / etiology*,  physiopathology,  prevention & control
Pregnancy
Pregnancy Trimesters
Prenatal Exposure Delayed Effects
Prospective Studies
Public Health*
Risk Assessment
Risk Factors
Sleep
Smoking / adverse effects
Time Factors
United States
Weight Gain
Grant Support
ID/Acronym/Agency:
HD 044807/HD/NICHD NIH HHS; HD 34568/HD/NICHD NIH HHS; HL 075504/HL/NHLBI NIH HHS; HL 64925/HL/NHLBI NIH HHS; HL 68041/HL/NHLBI NIH HHS; K23 HD044807/HD/NICHD NIH HHS; K23 HD044807-05/HD/NICHD NIH HHS; K24 HL068041/HL/NHLBI NIH HHS; K24 HL068041-06/HL/NHLBI NIH HHS; P30 DK040561/DK/NIDDK NIH HHS; P30 DK040561-13/DK/NIDDK NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HD034568-07/HD/NICHD NIH HHS; R01 HL064925/HL/NHLBI NIH HHS; R01 HL064925-05/HL/NHLBI NIH HHS; R01 HL075504/HL/NHLBI NIH HHS; R01 HL075504-04/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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