Document Detail


Developmental and nutritional regulation of the prepubertal heifer mammary gland: I. Parenchyma and fat pad mass and composition.
MedLine Citation:
PMID:  17033016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior to puberty, elevated nutrient intake has been shown to negatively affect prepubertal mammary development in the heifer. The objective of this study was to evaluate the effects of increased nutrient intake on mammary development in Holstein heifers at multiple body weights from birth through puberty. Specifically, this study evaluated the effects of nutrient intake and body weight at harvest on 1) total weight and DNA content of the parenchyma (PAR) and mammary fat pad (MFP) and 2) PAR and MFP composition. Starting at 45 kg of body weight, heifers (n = 78) were assigned to either a restricted (R) or elevated (E) level of nutrient intake supporting 650 (R) or 950 (E) g/d of body weight gain. Heifers were harvested at 50-kg increments from 100 to 350 kg of body weight. Mammary fat pad weight and DNA content were greater in E- than in R-heifers. Additionally, E-heifers had a greater fraction of lipids and a smaller fraction of protein in their MFP than did R-heifers. Parenchyma weight and DNA were lower in E- than in R-heifers; however, when analyzed with age as a covariate term, treatment was no longer a significant term in the model. Level of nutrient intake had no effect on the lipid, protein, or hydroxyproline composition of the PAR. Collectively, these data demonstrate that PAR is refractory to the level of nutrient intake whereas MFP is not. Furthermore, the covariate analysis demonstrated that age at harvest, not the level of nutrient intake, was the single greatest determinant of total PAR DNA content.
Authors:
M J Meyer; A V Capuco; D A Ross; L M Lintault; M E Van Amburgh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of dairy science     Volume:  89     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-11     Completed Date:  2008-05-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4289-97     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Cornell University, Ithaca, NY 14850, USA. mev1@cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / growth & development*,  physiology
Age Factors
Animal Feed / analysis
Animal Nutritional Physiological Phenomena / physiology*
Animals
Body Weight
Cattle / growth & development*
Diet / veterinary*
Female
Mammary Glands, Animal / growth & development*,  physiology
Ovulation / physiology
Sexual Maturation / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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