| Developmental lead exposure causes startle response deficits in zebrafish. | |
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MedLine Citation:
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PMID: 21955963 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lead (Pb(2+)) exposure continues to be an important concern for fish populations. Research is required to assess the long-term behavioral effects of low-level concentrations of Pb(2+) and the physiological mechanisms that control those behaviors. Newly fertilized zebrafish embryos (<2h post fertilization; hpf) were exposed to one of three concentrations of lead (as PbCl(2)): 0, 10, or 30nM until 24hpf. (1) Response to a mechanosensory stimulus: Individual larvae (168hpf) were tested for response to a directional, mechanical stimulus. The tap frequency was adjusted to either 1 or 4taps/s. Startle response was recorded at 1000fps. Larvae responded in a concentration-dependent pattern for latency to reaction, maximum turn velocity, time to reach V(max) and escape time. With increasing exposure concentrations, a larger number of larvae failed to respond to even the initial tap and, for those that did respond, ceased responding earlier than control larvae. These differences were more pronounced at a frequency of 4taps/s. (2) Response to a visual stimulus: Fish, exposed as embryos (2-24hpf) to Pb(2+) (0-10μM) were tested as adults under low light conditions (∼60μW/m(2)) for visual responses to a rotating black bar. Visual responses were significantly degraded at Pb(2+) concentrations of 30nM. These data suggest that zebrafish are viable models for short- and long-term sensorimotor deficits induced by acute, low-level developmental Pb(2+) exposures. |
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Authors:
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Clinton Rice; Jugal K Ghorai; Kathryn Zalewski; Daniel N Weber |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-27 |
Journal Detail:
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Title: Aquatic toxicology (Amsterdam, Netherlands) Volume: 105 ISSN: 1879-1514 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500246 Medline TA: Aquat Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: 600-608 Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biology, American University, Washington, DC 20016, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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