Document Detail


Developmental and genetic influences on the P50 sensory gating phenotype.
MedLine Citation:
PMID:  8645776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evoked potentials to pairs of click stimuli were recorded from 127 subjects ranging in age from 10 to 39 years to examine the developmental course of auditory sensory gating. The ratio of the amplitude of the second response to that of the first provides a quantitative measure of auditory sensory gating. Contrary to earlier results, the distribution of P50 ratios was unchanged between children and younger adolescents (10-14 years), older adolescents (15-19 years), and adults (20-29 and 30-39 years). Included in the sample were 39 adolescent twins, allowing assessment for possible genetic effects underlying the P50 sensory gating phenotype, by comparison of the similarity of the measure in monozygotic and same-sex dizygotic twin pairs. The monozygotic twins had significantly higher similarity for the P50 ratio within each twin pair than the dizygotic twins. These results are consistent with the presence of genetic influences on the P50 sensory gating phenotype.
Authors:
M Myles-Worsley; H Coon; W Byerley; M Waldo; D Young; R Freedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Twin Study    
Journal Detail:
Title:  Biological psychiatry     Volume:  39     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-95     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City 84132, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arousal / genetics*,  physiology
Child
Child Development / physiology*
Electroencephalography
Evoked Potentials, Auditory / genetics*,  physiology
Female
Fourier Analysis
Habituation, Psychophysiologic / genetics,  physiology
Humans
Male
Phenotype*
Reference Values
Signal Processing, Computer-Assisted
Twins, Dizygotic / genetics
Twins, Monozygotic / genetics
Grant Support
ID/Acronym/Agency:
MH38321/MH/NIMH NIH HHS; MH44212/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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