Document Detail

Developmental and genetic aspects of atrial fibrillation.
MedLine Citation:
PMID:  19818948     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. The abnormal rhythm is associated not only with a variety of symptoms, such as palpitations, dizziness, or shortness of breath, but also with increased risk of stroke, heart failure, and mortality. A genetic predisposition is suggested by the fact that the relative risk for the development of AF is estimated at 85% in individuals with at least one parent with a history of AF. Current therapeutic strategies include control of rate or rhythm with medication and catheter ablation procedures. Especially in the pathophysiology of paroxysmal AF, ectopic electrical activity originating in the myocardial sleeves surrounding the pulmonary veins is considered causal. In these cases, ablation is applied to isolate the pulmonary venous myocardium from the remainder of the left atrial myocardium. Other recent evidence has shown that genetic and developmental defects can be involved in the development of AF. In this review, it is our aim to discuss the possible underlying causes of AF from a combined genetic and cardiac developmental view.
Alex V Postma; Lukas R C Dekker; Alexandre T Soufan; Antoon F M Moorman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  19     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2009-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Atrial Fibrillation / embryology,  etiology*,  genetics,  therapy
Atrial Function / genetics
Catheter Ablation
Gene Expression Regulation, Developmental
Genetic Predisposition to Disease
Polymorphism, Genetic
Risk Assessment
Risk Factors
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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