Document Detail

Developmental expression of the three iroquois genes of amphioxus (BfIrxA, BfIrxB, and BfIrxC) with special attention to the gastrula organizer and anteroposterior boundaries in the central nervous system.
MedLine Citation:
PMID:  19233318     Owner:  NLM     Status:  MEDLINE    
Here we describe the developmental expression of the three iroquois genes (BfIrxA, BfIrxB, and BfIrxC) of amphioxus. BfIrxB transcription is first detected at the gastrula stage in mesendoderm just within the dorsal lip of the blastopore (a probable homolog of Spemann's organizer) and in ectoderm. In early neurulae, expression begins in presumptive pharyngeal endoderm, somitic mesoderm, and neural plate. Mid-neurulae express BfIrxB throughout the hindbrain, posterior somites, pharyngeal endoderm, and notochord. In early larvae, expression is largely downregulated in the nerve cord, somites and notochord, but remains strong in the pharyngeal endoderm associated with the forming gill slits; also, a late expression domain appears in the ciliary tuft ectoderm. BfIrxA and BfIrxC, are not as widely expressed as BfIrxB. Both are first expressed in the presumptive hindbrain and presumptive pharyngeal endoderm at the early neurula stages. In the mid-neurula, additional expression domains appear in the extremities of the notochord. Neural expression is downregulated by late neurula. In the early larva, expression is chiefly limited to pharyngeal endoderm associated with the forming gill slits, excepting a small new domain of BfIrxC (not BfIrxA) expression in the ciliary tuft ectoderm. In comparison to developing vertebrates, embryos and larvae of amphioxus express iroquois genes in fewer tissues. Thus, iroquois genes of the proximate ancestor of the vertebrates evidently assumed numerous new roles during vertebrate evolution, including the division of the central nervous system into several sub-regions along its anteroposterior axis.
Stacy L Kaltenbach; Linda Z Holland; Nicholas D Holland; Demian Koop
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-02-20
Journal Detail:
Title:  Gene expression patterns : GEP     Volume:  9     ISSN:  1567-133X     ISO Abbreviation:  Gene Expr. Patterns     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167473     Medline TA:  Gene Expr Patterns     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Marine Biology Research Division, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0202, USA.
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MeSH Terms
Central Nervous System / embryology,  metabolism*
Chordata, Nonvertebrate / embryology,  genetics*
Gastrula / metabolism*
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Homeodomain Proteins / genetics*
In Situ Hybridization
Multigene Family / genetics
Transcription Factors / genetics*
Reg. No./Substance:
0/Homeodomain Proteins; 0/Transcription Factors

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