Document Detail

Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia.
MedLine Citation:
PMID:  19039786     Owner:  NLM     Status:  MEDLINE    
Intracellular membrane trafficking regulates a wide variety of developmental processes, including cell and tissue morphogenesis. Here we report developmental expression of Drosophila Rab11, a small GTP-binding protein, required for both endocytic recycling and exocytosis. Rab11 is expressed in the epithelial cell types of diverse lineages at all developmental stages, beginning from the cellular blastoderm in early embryos to adult primordia and adult tissues, like the columnar epithelia lining male ejaculatory bulb. A robust expression of Rab11 is seen both in the amnioserosa and in the lateral epidermis during embryonic dorsal closure, a morphogenetic event that involves spreading and fusion of the contra-lateral sides of epidermis. Rab11 mutant embryos fail to display the characteristic morphological changes in these two epithelial tissues during dorsal closure, providing a strong basis to dissect the role of Rab11 in coordinated epithelial sheet movements. genesis 47:32-39, 2009. (c) 2008 Wiley-Liss, Inc.
Satish Sasikumar; Jagat Kumar Roy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  47     ISSN:  1526-968X     ISO Abbreviation:  Genesis     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-9     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Wiley-Liss, Inc.
Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India.
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MeSH Terms
Drosophila / embryology,  genetics,  growth & development,  metabolism*
Embryo, Nonmammalian / embryology,  metabolism
Epithelium / embryology,  metabolism*
Gene Expression Regulation, Developmental*
Golgi Apparatus / metabolism
rab GTP-Binding Proteins / genetics,  metabolism*
Reg. No./Substance:
EC 3.6.1.-/rab GTP-Binding Proteins; EC 3.6.1.-/rab11 protein

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