| Developmental expression of GABA transporters GAT1 and GAT4 suggests involvement in brain maturation. | |
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MedLine Citation:
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PMID: 8764616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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cDNA clones representing four pharmacologically distinct GABA transporters (GAT1-GAT4) were previously identified in mouse brain. Two of these, GAT1 and GAT4, were found to be brain specific. We studied GAT1 and GAT4 in the developing rat brain using polygonal antibodies against recombinant fusion proteins. Patterns of immunoreactivity were very similar in the embryonic and early postnatal stages for both transporters. However, whereas GAT1 immunoreactivity was detected in distinct patterns in gray matter and growing axons, GAT4 immunoreactivity was found in a subset of radial glial cell fascicles. These patterns usually oriented perpendicularly to the axons expressing GAT1. Our results suggest a transient relationship between GAT4-expressing radial glial elements and GAT1-expressing axons. The presence of GAT1 in the cortical marginal zone and the numerous GAT4-positive fascicles observed in the fetal anterior commissure indicate that both transporters may play a role in processes of brain maturation. Because the beginning of expression for both GAT1 and GAT4 correlates with the expression of the alpha1 subunit of the GABA receptor, the transporters may be connected with the maturation of adult-type GABAergic inhibitory system in the brain. |
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Authors:
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F Jursky; N Nelson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurochemistry Volume: 67 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-19 Completed Date: 1996-09-19 Revised Date: 2006-11-20 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 857-67 Citation Subset: IM |
Affiliation:
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Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Brain / embryology, metabolism* Carrier Proteins / metabolism* Cell Compartmentation GABA Plasma Membrane Transport Proteins Immunoenzyme Techniques Membrane Proteins / metabolism* Membrane Transport Proteins* Neuroglia / metabolism Neurons / physiology Organic Anion Transporters* Rats gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/GABA Plasma Membrane Transport Proteins; 0/Gabt4 protein, mouse; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/Organic Anion Transporters; 0/Slc6a1 protein, mouse; 0/Slc6a1 protein, rat; 56-12-2/gamma-Aminobutyric Acid |
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