Document Detail


Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function.
MedLine Citation:
PMID:  17140764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Female reproductive function depends upon the exquisite control of ovarian steroidogenesis that enables folliculogenesis, ovulation, and pregnancy. These mechanisms are set during fetal and/or neonatal development and undergo phases of differentiation throughout pre- and post-pubescent life. Ovarian development and function are collectively regulated by a host of endogenous growth factors, cytokines, gonadotropins, and steroid hormones as well as exogenous factors such as nutrients and environmental agents. Endocrine disruptors represent one class of environmental agent that can impact female fertility by altering ovarian development and function, purportedly through estrogenic, anti-estrogenic, and/or anti-androgenic effects. This review discusses ovarian development and function and how these processes are affected by some of the known estrogenic and anti-androgenic endocrine disruptors. Recent information suggests not only that exposure to endocrine disruptors during the developmental period causes reproductive abnormalities in adult life but also that these abnormalities are transgenerational. This latter finding adds another level of importance for identifying and understanding the mechanisms of action of these agents.
Authors:
Mehmet Uzumcu; Rob Zachow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-11-06
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  23     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2007 Apr-May
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-09-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic Development / drug effects
Endocrine Disruptors / chemistry,  poisoning*
Environmental Pollutants / chemistry,  poisoning*
Female
Humans
Ovary / drug effects*,  embryology
Pregnancy
Prenatal Exposure Delayed Effects
Reproduction / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
R21 ES013854/ES/NIEHS NIH HHS; R21 ES013854-01A1/ES/NIEHS NIH HHS; R21 ES013854-01A1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Environmental Pollutants
Comments/Corrections

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