Document Detail

Developmental evolution and the origins of phenotypic variation.
MedLine Citation:
PMID:  25372764     Owner:  NLM     Status:  In-Data-Review    
Abstract Because of the variability of relevant developmental resources across different environments, and because only a portion of the genome is expressed in any individual organism as a result of its specific developmental context and experience, what is actually realized during the course of individual development represents only one of many possibilities. One conclusion to be drawn from this insight is that the origin of phenotypic traits and their variation can be traced to the process of development. In this conceptual overview, I briefly explore how recent efforts to integrate genetic, epigenetic, and environmental levels of analysis through a developmental lens is advancing our understanding of the generation of the stability and variability of phenotypic outcomes observed within and across generations. A growing body of evidence indicates that phenotypes are the outcomes of the whole developmental system, comprised of the organism, with its particular genetic and cellular make-up in its specific physical, biological, and social environments. I conclude that the emergent products of development are epigenetic, not just genetic, and evolutionary explanation cannot be complete without a developmental mode of analysis.
Robert Lickliter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomolecular concepts     Volume:  5     ISSN:  1868-503X     ISO Abbreviation:  Biomol Concepts     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-11-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518829     Medline TA:  Biomol Concepts     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  343-52     Citation Subset:  IM    
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