| Developmental electrophysiologic effects of propafenone and 5-hydroxypropafenone on the canine cardiac Purkinje fiber. | |
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MedLine Citation:
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PMID: 1811919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Standard microelectrode techniques were used to investigate the in vitro developmental electrophysiologic effects of propafenone and 5-hydroxypropafenone on the adult and neonatal canine Purkinje fiber. The tonic and frequency-dependent depressant effects of these compounds on Vmax and amplitude were similar in both age groups. However, the ability of these compounds to shorten repolarization parameters was more pronounced in the adult. The extent of reduction of abnormal automaticity produced by propafenone was greater in the neonate compared to the adult, and 5-hydroxypropafenone significantly reduced automaticity only in the neonate. The sensitivity of neonatal abnormal automaticity to the effects of these compounds may prove to be important if the use of these agents is to be expanded into the realm of therapy for pediatric automatic rhythms. |
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Authors:
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C L Case; R R Ravin; R Maheshwari; P C Gillette; K W Hewett |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 17 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1991 |
Date Detail:
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Created Date: 1992-06-09 Completed Date: 1992-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 24-34 Citation Subset: IM |
Affiliation:
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South Carolina Children's Heart Center, Medical University of South Carolina, Charleston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn / growth & development Anti-Arrhythmia Agents / pharmacology* Dogs Electrophysiology Female Male Membrane Potentials / drug effects Propafenone / analogs & derivatives*, pharmacology* Purkinje Fibers / drug effects*, growth & development |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone; 86384-10-3/5-hydroxypropafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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