Document Detail


Developmental electrophysiologic effects of propafenone and 5-hydroxypropafenone on the canine cardiac Purkinje fiber.
MedLine Citation:
PMID:  1811919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Standard microelectrode techniques were used to investigate the in vitro developmental electrophysiologic effects of propafenone and 5-hydroxypropafenone on the adult and neonatal canine Purkinje fiber. The tonic and frequency-dependent depressant effects of these compounds on Vmax and amplitude were similar in both age groups. However, the ability of these compounds to shorten repolarization parameters was more pronounced in the adult. The extent of reduction of abnormal automaticity produced by propafenone was greater in the neonate compared to the adult, and 5-hydroxypropafenone significantly reduced automaticity only in the neonate. The sensitivity of neonatal abnormal automaticity to the effects of these compounds may prove to be important if the use of these agents is to be expanded into the realm of therapy for pediatric automatic rhythms.
Authors:
C L Case; R R Ravin; R Maheshwari; P C Gillette; K W Hewett
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  17     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  24-34     Citation Subset:  IM    
Affiliation:
South Carolina Children's Heart Center, Medical University of South Carolina, Charleston.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn / growth & development
Anti-Arrhythmia Agents / pharmacology*
Dogs
Electrophysiology
Female
Male
Membrane Potentials / drug effects
Propafenone / analogs & derivatives*,  pharmacology*
Purkinje Fibers / drug effects*,  growth & development
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone; 86384-10-3/5-hydroxypropafenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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