| Developmental effects of ethinylestradiol on reproductive organs of female mice. | |
| | |
MedLine Citation:
|
PMID: 17203781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Reproductive organs in female mice are susceptible to exposure to estrogenic substances especially during development. In the present study, C57BL/6J female mice were exposed to the synthetic estrogens ethinylestradiol (EE2) or diethylstilbestrol (DES), 10-100 or 6.7-67 microg/kg bw, respectively, in utero from day 10 to 18 of pregnancy, and their effects were analyzed at 30 and 40 days of age. Both EE2 and DES reduced the survival rate of fetuses and newborns in a dose-dependent manner. Polyovular follicles (PF) were found in the ovaries of all groups at 30 days of age including oil-injected controls. However, the incidence of PF was significantly higher in the 50 microg/kg EE2- and 33.3 microg/kg DES-exposed mice than the control. In vaginal epithelia of the in utero EE2 exposed, ovariectomized mice, stratification and cornification were encountered even 10 days after ovariectomy. Especially, vaginae in the ovariectomized mice given high dose of EE2 or DES in utero showed ovary-independent proliferation of the epithelium. Thus, it is clear that prenatal exposure to EE2 or DES induces reproductive abnormalities, including PF, ovary-independent vaginal epithelial stratification and cornification. |
| | |
Authors:
|
Akiko Kirigaya; Shinji Hayashi; Taisen Iguchi; Tomomi Sato |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: In vivo (Athens, Greece) Volume: 20 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2006 Nov-Dec |
Date Detail:
|
Created Date: 2007-01-05 Completed Date: 2007-02-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
|
Languages: eng Pagination: 867-73 Citation Subset: IM |
Affiliation:
|
Graduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Drug-Induced
/
mortality,
pathology Animals Body Weight / drug effects Cell Proliferation / drug effects Diethylstilbestrol / pharmacology, toxicity Epithelial Cells / drug effects, pathology Epithelium / drug effects, pathology Estrogens / pharmacology, toxicity Ethinyl Estradiol / pharmacology*, toxicity Fallopian Tubes / drug effects, pathology Female Fetal Weight / drug effects Genitalia, Female / drug effects, pathology* Litter Size / drug effects Mice Mice, Inbred C57BL Organ Size / drug effects Ovarian Follicle / drug effects, pathology Ovary / drug effects, pathology Pregnancy Prenatal Exposure Delayed Effects / chemically induced*, pathology Stromal Cells / drug effects, pathology Survival Rate Uterus / drug effects, pathology Vagina / drug effects, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Estrogens; 56-53-1/Diethylstilbestrol; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A...
Next Document: Effect of exercise on oxidative stress in individuals with glucose-6-phosphate dehydrogenase deficie...