Document Detail


Developmental effects of ethinylestradiol on reproductive organs of female mice.
MedLine Citation:
PMID:  17203781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reproductive organs in female mice are susceptible to exposure to estrogenic substances especially during development. In the present study, C57BL/6J female mice were exposed to the synthetic estrogens ethinylestradiol (EE2) or diethylstilbestrol (DES), 10-100 or 6.7-67 microg/kg bw, respectively, in utero from day 10 to 18 of pregnancy, and their effects were analyzed at 30 and 40 days of age. Both EE2 and DES reduced the survival rate of fetuses and newborns in a dose-dependent manner. Polyovular follicles (PF) were found in the ovaries of all groups at 30 days of age including oil-injected controls. However, the incidence of PF was significantly higher in the 50 microg/kg EE2- and 33.3 microg/kg DES-exposed mice than the control. In vaginal epithelia of the in utero EE2 exposed, ovariectomized mice, stratification and cornification were encountered even 10 days after ovariectomy. Especially, vaginae in the ovariectomized mice given high dose of EE2 or DES in utero showed ovary-independent proliferation of the epithelium. Thus, it is clear that prenatal exposure to EE2 or DES induces reproductive abnormalities, including PF, ovary-independent vaginal epithelial stratification and cornification.
Authors:
Akiko Kirigaya; Shinji Hayashi; Taisen Iguchi; Tomomi Sato
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  20     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2007-01-05     Completed Date:  2007-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  867-73     Citation Subset:  IM    
Affiliation:
Graduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / mortality,  pathology
Animals
Body Weight / drug effects
Cell Proliferation / drug effects
Diethylstilbestrol / pharmacology,  toxicity
Epithelial Cells / drug effects,  pathology
Epithelium / drug effects,  pathology
Estrogens / pharmacology,  toxicity
Ethinyl Estradiol / pharmacology*,  toxicity
Fallopian Tubes / drug effects,  pathology
Female
Fetal Weight / drug effects
Genitalia, Female / drug effects,  pathology*
Litter Size / drug effects
Mice
Mice, Inbred C57BL
Organ Size / drug effects
Ovarian Follicle / drug effects,  pathology
Ovary / drug effects,  pathology
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced*,  pathology
Stromal Cells / drug effects,  pathology
Survival Rate
Uterus / drug effects,  pathology
Vagina / drug effects,  pathology
Chemical
Reg. No./Substance:
0/Estrogens; 56-53-1/Diethylstilbestrol; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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