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Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
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MedLine Citation:
PMID:  8080506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Large numbers and large quantities of endocrine-disrupting chemicals have been released into the environment since World War II. Many of these chemicals can disturb development of the endocrine system and of the organs that respond to endocrine signals in organisms indirectly exposed during prenatal and/or early postnatal life; effects of exposure during development are permanent and irreversible. The risk to the developing organism can also stem from direct exposure of the offspring after birth or hatching. In addition, transgenerational exposure can result from the exposure of the mother to a chemical at any time throughout her life before producing offspring due to persistence of endocrine-disrupting chemicals in body fat, which is mobilized during egg laying or pregnancy and lactation. Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Authors:
T Colborn; F S vom Saal; A M Soto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  101     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-04-07     Completed Date:  1994-04-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  378-84     Citation Subset:  IM    
Affiliation:
W. Alton Jones Foundation, Washington, DC 20037.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Wild*
Diethylstilbestrol / adverse effects
Embryonic and Fetal Development / drug effects
Endocrine Glands / drug effects*,  growth & development
Environmental Pollutants / adverse effects*
Estrogens / adverse effects
Female
Humans
Male
Models, Biological
Risk Factors
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Estrogens; 56-53-1/Diethylstilbestrol
Comments/Corrections
Comment In:
Environ Health Perspect. 1994 Mar;102(3):256-7   [PMID:  8033855 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 10 Year: 1993
Volume: 101 Issue: 5
First Page: 378 Last Page: 384
ID: 1519860
PubMed Id: 8080506

Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
T Colborn
F S vom Saal
A M Soto
W. Alton Jones Foundation, Washington, DC 20037.



Article Categories:
  • Research Article


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