Document Detail

Developmental delay of astrocytes in hippocampus of rhesus monkeys reflects the effect of pre- and postnatal chronic low level lead exposure.
MedLine Citation:
PMID:  7854604     Owner:  NLM     Status:  MEDLINE    
Rhesus monkeys were pre- and postnatally exposed to lead-acetate at 0, 350, or 600 ppm in diet for nine years, followed by a period of lead-free diet for 32 months. During this time blood lead levels declined to normal, but still showed dose-related differences. In behavioral and neurophysiological studies the rhesus monkeys exhibited dose-related cognitive and functional deficits. After sacrifice hippocampal sections were processed for immunohistological staining. GFAP, introduced as a marker of neurotoxicity and Vimentin, which is expressed by immature or reactive astrocytes were investigated. A dose-dependent increase of GFAP due to prenatal and chronic low level lead exposure was not observed. We found a dose-related increase of GFAP-positive radial glia and star-shaped Vimentin-positive astrocytes in the high lead group. We consider these findings as indication of immature astrocytes, which are not able to react with gliosis in respond to pre- and postnatal low level lead exposure. The lack of pronounced glial response due to low level lead exposure may result in a delay of astrocytic differentiation, shown by persistence of radial glia.
K Buchheim; S Noack; G Stoltenburg; H Lilienthal; G Winneke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  15     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-9     Citation Subset:  IM    
Institute of Neuropathology, Freie Universitaet Berlin, Germany.
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MeSH Terms
Astrocytes / drug effects*
Dose-Response Relationship, Drug
Fetus / drug effects*
Glial Fibrillary Acidic Protein / analysis
Hippocampus / chemistry,  drug effects*
Lead / toxicity*
Macaca mulatta
Vimentin / analysis
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/Vimentin; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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