| Developmental decisions: balancing genetics and the environment by C. elegans. | |
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MedLine Citation:
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PMID: 22510569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The small nematode C. elegans is characterized by developing through a highly coordinated, reproducible cell lineage that serves as the basis of many studies focusing on the development of multi-lineage organisms. Indeed, the reproducible cell lineage enables discovery of developmental defects that occur in even a single cell. Only recently has attention been focused on how these animals modify their genetically programmed cell lineages to adapt to altered environments. Here, we summarize the current understanding of how C. elegans responds to food deprivation by adapting their developmental program in order to conserve energy. In particular, we highlight the AMPK-mediated and insulin-like growth factor signaling pathways that are the principal regulators of induced cell cycle quiescence. |
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Authors:
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David V Tobin; Richard Mako Saito |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-05-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 11 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-17 Completed Date: 2012-09-17 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1666-71 Citation Subset: IM |
Affiliation:
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Department of Genetics, Dartmouth Medical School, Hanover, NH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AMP-Activated Protein Kinases
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genetics,
metabolism Adaptation, Physiological Animals Caenorhabditis elegans / genetics, metabolism, physiology* Caenorhabditis elegans Proteins / genetics, metabolism Cell Cycle Checkpoints Cell Division Cell Lineage Environment* Food Deprivation / physiology Germ Cells / cytology, metabolism, physiology Insulin-Like Growth Factor I / genetics, metabolism* Receptor Cross-Talk Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
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GM077031/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.11.1/AMP-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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