Document Detail

Developmental decisions: balancing genetics and the environment by C. elegans.
MedLine Citation:
PMID:  22510569     Owner:  NLM     Status:  MEDLINE    
The small nematode C. elegans is characterized by developing through a highly coordinated, reproducible cell lineage that serves as the basis of many studies focusing on the development of multi-lineage organisms. Indeed, the reproducible cell lineage enables discovery of developmental defects that occur in even a single cell. Only recently has attention been focused on how these animals modify their genetically programmed cell lineages to adapt to altered environments. Here, we summarize the current understanding of how C. elegans responds to food deprivation by adapting their developmental program in order to conserve energy. In particular, we highlight the AMPK-mediated and insulin-like growth factor signaling pathways that are the principal regulators of induced cell cycle quiescence.
David V Tobin; Richard Mako Saito
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-01
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-17     Completed Date:  2012-09-17     Revised Date:  2013-08-05    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1666-71     Citation Subset:  IM    
Department of Genetics, Dartmouth Medical School, Hanover, NH, USA.
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MeSH Terms
AMP-Activated Protein Kinases / genetics,  metabolism
Adaptation, Physiological
Caenorhabditis elegans / genetics,  metabolism,  physiology*
Caenorhabditis elegans Proteins / genetics,  metabolism
Cell Cycle Checkpoints
Cell Division
Cell Lineage
Food Deprivation / physiology
Germ Cells / cytology,  metabolism,  physiology
Insulin-Like Growth Factor I / genetics,  metabolism*
Receptor Cross-Talk
Signal Transduction*
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 67763-96-6/Insulin-Like Growth Factor I; EC Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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