Document Detail

Developmental correlation between hypothalamic somatostatin and hypophysial growth hormone.
MedLine Citation:
PMID:  391394     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to determine, by means of immunocytochemistry, the age in fetal development at which GH is first detectable in the pituitary gland and somatostatin in the median eminence, and to correlate temporally the development of these two hormones throughout the remainder of pregnancy. Mice were studied at 15-19 days of gestation with the peroxidase-antiperoxidase (PAP) technique of Sternberger. Somatotropes in the pars distalis were initially detected at 16 days of gestation and by 17 days they were a prominent component of the parenchymal cell population of the hypophysis. These cells were ovoid and distributed unformly throughout the pars distalis; many were located adjacent to sinusoidal capillaries. Their number and staining intensity increased by 19 days. Somatostatin was not consistently observed in the median eminence until 19 days of gestation. Reaction product indicative of the presence of somatostatin in presumptive nerve endings was located on the ventral surface of the median eminence and in the external lamina of the infundibulum in proximity to the superficial portal capillaries. Results of the present in investigation support the concept that the potential for neuroendocrine control of GH secretion exists in the mouse by the end of fetal development. Several hypotheses concerning the temporal relationship between the appearance of somatostatin in the hypothalamus and of GH in the anterior pituitary gland are discussed.
D S Gross; J D Longer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell and tissue research     Volume:  202     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  251-61     Citation Subset:  IM    
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MeSH Terms
Fetus / metabolism*
Gestational Age
Growth Hormone / metabolism*
Hypothalamo-Hypophyseal System / metabolism*
Immunoenzyme Techniques
Median Eminence / embryology,  metabolism*
Pituitary Gland / embryology,  metabolism*
Somatostatin / metabolism*
Reg. No./Substance:
51110-01-1/Somatostatin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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