Document Detail

Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate.
MedLine Citation:
PMID:  20554442     Owner:  NLM     Status:  MEDLINE    
The temporal and spatial segregation of the two extra-embryonic cell lineages, trophectoderm and primitive endoderm (TE and PE respectively), from the pluripotent epiblast (EPI) during mammalian pre-implantation development are prerequisites for the successful implantation of the blastocyst. The mechanisms underlying these earliest stages of development remain a fertile topic for research and informed debate. In recent years novel roles for various transcription factors, polarity factors and signalling cascades have been uncovered. This mini-review seeks to summarise some of this work and to put it into the context of the regulative nature of early mammalian development and to highlight how the increasing evidence of naturally occurring asymmetries and heterogeneity in the embryo can bias specification of the distinct cell types of the blastocyst.
Alexander W Bruce; Magdalena Zernicka-Goetz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-14
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  20     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-12-21     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Blastocyst / cytology
Cell Lineage
Cell Polarity
Embryo Implantation*
Embryo, Mammalian / embryology*
Embryonic Development*
Endoderm / cytology,  growth & development
Pluripotent Stem Cells / physiology*
Transcription Factors / metabolism*
Grant Support
064421//Wellcome Trust; G0800784//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Transcription Factors

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