| Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. | |
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MedLine Citation:
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PMID: 20554442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The temporal and spatial segregation of the two extra-embryonic cell lineages, trophectoderm and primitive endoderm (TE and PE respectively), from the pluripotent epiblast (EPI) during mammalian pre-implantation development are prerequisites for the successful implantation of the blastocyst. The mechanisms underlying these earliest stages of development remain a fertile topic for research and informed debate. In recent years novel roles for various transcription factors, polarity factors and signalling cascades have been uncovered. This mini-review seeks to summarise some of this work and to put it into the context of the regulative nature of early mammalian development and to highlight how the increasing evidence of naturally occurring asymmetries and heterogeneity in the embryo can bias specification of the distinct cell types of the blastocyst. |
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Authors:
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Alexander W Bruce; Magdalena Zernicka-Goetz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-14 |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 20 ISSN: 1879-0380 ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-12-21 Revised Date: 2011-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 485-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom. awbruce@prf.jcu.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / cytology Cell Lineage Cell Polarity Embryo Implantation* Embryo, Mammalian / embryology* Embryonic Development* Endoderm / cytology, growth & development Pluripotent Stem Cells / physiology* Transcription Factors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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064421//Wellcome Trust; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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