Document Detail


Developmental characteristics of vessel density in the human fetal and infant brains.
MedLine Citation:
PMID:  10193927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrated the developmental characteristics of vessel density in the human brain, using an antibody against CD31, which specifically reacts with endothelium. In the cerebral cortex and subcortical white matter, the vessel density was low at 16-28 weeks of gestation (GW), and then increased after 36 GW. In the deep white matter, the vessel density was high in the middle fetal period (16-24 GW), and then transiently decreased at 28-36 GW, and increasing after 39 GW. In the putamen, the vessel density was high at 20-21 GW, remained high throughout the fetal period, and then rapidly increased after birth. In the basis pontis, the number of vessels increased after 28 GW, and after 32 GW was greater than in the pontine tegmentum. These alterations in vessel density may correlate with the pathogenesis of perinatal brain injury. Thus, the transient decrease of vessel density in the deep white matter may predispose to periventricular leukomalacia in cerebral hypoperfusion. Similarly, the well-developed vascularity in the basis pontis may predispose its relatively immature neurons to neuron necrosis produced by free radical injury.
Authors:
T Miyawaki; K Matsui; S Takashima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  53     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Affiliation:
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aging
Antigens, CD31 / analysis
Blood Vessels / embryology*,  growth & development*
Brain / blood supply*,  embryology,  growth & development
Endothelium, Vascular / chemistry
Epithelium / chemistry
Frontal Lobe / blood supply
Gestational Age
Humans
Immunoenzyme Techniques
Infant
Infant, Newborn
Membrane Glycoproteins / analysis
Microcirculation / chemistry
Pons / blood supply
Putamen / blood supply
Chemical
Reg. No./Substance:
0/Antigens, CD31; 0/Membrane Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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