| Developmental changes of sialylation of soluble beta/A4 amyloid protein precursor derivatives in human cerebrospinal fluid. | |
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MedLine Citation:
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PMID: 7898317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soluble beta/A4 amyloid protein precursor derivatives (APPs) in cerebrospinal fluid from infants, children, adults and aged individuals were treated with neuraminidase. In the samples from infants, reduction of molecular weight of APPs following neuraminidase treatment was significantly less than those from adults or aged individuals. Hyposialylation of beta/A4 amyloid protein precursor in infants may be relevant to a physiological role of this molecule in the development of the nervous system. |
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Authors:
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N Sodeyama; F Saito; K Saito; T Miyatake; K Yanagisawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research. Molecular brain research Volume: 27 ISSN: 0169-328X ISO Abbreviation: Brain Res. Mol. Brain Res. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-04-25 Completed Date: 1995-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908640 Medline TA: Brain Res Mol Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 320-2 Citation Subset: IM |
Affiliation:
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Department of Neurology, School of Medicine, Tokyo Medical and Dental University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Alzheimer Disease / cerebrospinal fluid Amyloid beta-Protein Precursor / cerebrospinal fluid*, genetics Antibodies Blotting, Western Child Humans Infant Molecular Weight N-Acetylneuraminic Acid Neuraminidase Sialic Acids / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein Precursor; 0/Antibodies; 0/Sialic Acids; 131-48-6/N-Acetylneuraminic Acid; EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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