Document Detail

Developmental changes of sheep surfactant: in vivo function and in vitro subtype conversion.
MedLine Citation:
PMID:  7928903     Owner:  NLM     Status:  MEDLINE    
Developmental differences in the intrinsic characteristics of surfactant have not been evaluated. Therefore, heavy-subtype surfactant was recovered from alveolar washes of 132-, 139-, and 148-day preterm lambs, 2- to 3-day-old newborn ventilated lambs, and adult sheep. The density of heavy-subtype surfactant and surfactant protein-A-to-saturated phosphatidylcholine ratios increased significantly with developmental age. In contrast, percent conversion from heavy to light surfactant forms was more rapid for surfactant from preterm animals than for surfactant from mature or adult animals. The function of the heavy-subtype surfactant was tested by treating ventilated 27-day gestational age preterm rabbits. The surfactant from the most immature animals was less effective at improving compliance or maintaining lung volumes on deflation than was surfactant from newborn or adult animals. These results demonstrate intrinsic and functional differences in surfactant from developing compared with mature sheep that correlated with the surfactant protein-A-content. The pattern of changes indicates that the preterm animal is at a disadvantage, because the surfactant is intrinsically abnormal relative to that of the adult.
T Ueda; M Ikegami; A H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  76     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-01     Completed Date:  1994-11-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2701-6     Citation Subset:  IM    
Department of Pediatrics, Harbor-UCLA Medical Center, University of California Los Angeles School of Medicine, Torrance 90509.
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MeSH Terms
Aging / physiology
Animals, Newborn
Body Weight / physiology
Carbon Dioxide / metabolism
Gestational Age
Hydrogen-Ion Concentration
Infant, Newborn
Lung Compliance / physiology
Oxygen Consumption / physiology
Phosphatidylcholines / metabolism
Proteolipids / metabolism
Pulmonary Alveoli / metabolism
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants / chemistry,  metabolism*,  physiology*
Respiratory Distress Syndrome, Newborn / metabolism
Grant Support
Reg. No./Substance:
0/Phosphatidylcholines; 0/Proteolipids; 0/Pulmonary Surfactant-Associated Proteins; 0/Pulmonary Surfactants; 124-38-9/Carbon Dioxide

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