Document Detail

Developmental changes in the relation between phosphate metabolites and oxygen consumption in the sheep heart in vivo.
MedLine Citation:
PMID:  2913049     Owner:  NLM     Status:  MEDLINE    
This study examines the role of phosphate metabolites in the regulation of mitochondrial oxygen consumption of the heart in vivo as a function of development. We used an open chest lamb/sheep preparation in which myocardial oxygen consumption (MVO2) was monitored via an extracorporeal shunt from the coronary sinus. Phosphate metabolites were monitored simultaneously using 31P nuclear magnetic resonance with a surface coil overlying the left ventricle. Graded infusions of epinephrine were used to increase MVO2 in both neonatal lambs (age 5-12 d, n = 8), and mature sheep (26-86 d, n = 6). The maximal increase in MVO2 achieved was 220 +/- 38% in the newborns and 350 +/- 66% in the mature animals. Associated with these increases in MVO2 in the newborn lambs are significant (P less than 0.001) decreases in PCr/ATP, and increases in calculated ADP and intracellular Pi. This was in contrast to the mature sheep, in which there were no significant changes in PCr/ATP, ADP, or Pi. In conclusion, we find that (a) there are changes in PCr/ATP, Pi, and ADP in newborn animals with moderate increases in work that are not apparent in mature animals of the same species and (b) that these changes suggest that cytosolic ATP hydrolysis products may be more important in regulation of myocardial energy metabolism in the newborn than in the adult.
M A Portman; F W Heineman; R S Balaban
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  83     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-09     Completed Date:  1989-03-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-64     Citation Subset:  AIM; IM    
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.
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MeSH Terms
Adenosine Triphosphate / metabolism
Animals, Newborn
Epinephrine / pharmacology
Heart / drug effects
Myocardium / metabolism*
Oxygen Consumption*
Phosphates / metabolism*
Phosphocreatine / metabolism
Grant Support
Reg. No./Substance:
0/Phosphates; 51-43-4/Epinephrine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

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