| Developmental changes in neuronal sensitivity to excitatory amino acids in area CA1 of the rat hippocampus. | |
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MedLine Citation:
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PMID: 3282616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The laminar distribution of decreases in extracellular free calcium and concomitant field potentials induced by repetitive orthodromic stimulation, ionophoretic application of N-methyl-D-aspartate and quisqualate, was studied in the CA1 field of rat hippocampal slices, at two different stages during postnatal development. While stimulation-elicited and quisqualate-induced signals remain maximal in stratum pyramidale during the first postnatal month, the laminar profiles of responses to N-methyl-D-aspartate (NMDA) depend on age: the responses to this agonist are maximal in stratum pyramidale in 5-9-day-old rats and in stratum radiatum in 12-30-day-old rats. Our findings suggest that, during the second postnatal week, the apical dendrites of pyramidal neurons in area CAl become more sensitive to NMDA, which is expressed by big influxes of calcium at this level. |
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Authors:
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B Hamon; U Heinemann |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 466 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-05-27 Completed Date: 1988-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 286-90 Citation Subset: IM |
Affiliation:
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Abteilung Neurophysiologie, Max Planck Institut fuer Psychiatrie, Planegg-Martinsried, F.R.G. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Aging / physiology* Animals Aspartic Acid / analogs & derivatives*, pharmacology Electric Stimulation Hippocampus / drug effects, physiology* Male N-Methylaspartate Oxadiazoles / pharmacology* Quisqualic Acid Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Oxadiazoles; 52809-07-1/Quisqualic Acid; 56-84-8/Aspartic Acid; 6384-92-5/N-Methylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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