| Developmental changes in hepatic esterase activity towards chloramphenicol succinate and its Michaelis-Menten constant of liver, kidney and lung in human. | |
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MedLine Citation:
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PMID: 6723494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hepatic esterase activities towards chloramphenicol succinate were determined in the tissues from 45 human subjects, including 18 electively aborted fetuses, 5 premature and 8 full-term newborn babies, 8 infants and 6 adults. The enzyme activities in the tissues from the fetuses and neonates were significantly lower compared with those obtained from the infants and adults. This suggests that the activity showed postnatal development. Kinetic studies of the esterase activity revealed that hepatic Km values were similar to those of the lung, but renal Km values were about 3 times higher than those of the liver and lung. In each organ, no age-related changes in Km values were observed. However, all the Vmax values in each organ showed developmental increases. Therefore, the liver plays the most important role in hydrolysis of chloramphenicol succinate when the weight of the organ is taken into consideration. |
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Authors:
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T Yamakawa; S Itoh; S Onishi; K Isobe; A Hosoe; Y Nishimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 7 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1984 |
Date Detail:
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Created Date: 1984-07-16 Completed Date: 1984-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 205-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aging Child, Preschool Chloramphenicol / analogs & derivatives*, metabolism Esterases / blood, metabolism* Female Fetus / metabolism Gestational Age Humans Hydrolysis Infant Infant, Newborn Kidney / enzymology* Kinetics Liver / enzymology*, physiology Lung / enzymology* Male Middle Aged Pregnancy |
| Chemical | |
Reg. No./Substance:
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3544-94-3/chloramphenicol succinate; 56-75-7/Chloramphenicol; EC 3.1.-/Esterases |
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