Document Detail

Developmental changes in hepatic esterase activity towards chloramphenicol succinate and its Michaelis-Menten constant of liver, kidney and lung in human.
MedLine Citation:
PMID:  6723494     Owner:  NLM     Status:  MEDLINE    
The hepatic esterase activities towards chloramphenicol succinate were determined in the tissues from 45 human subjects, including 18 electively aborted fetuses, 5 premature and 8 full-term newborn babies, 8 infants and 6 adults. The enzyme activities in the tissues from the fetuses and neonates were significantly lower compared with those obtained from the infants and adults. This suggests that the activity showed postnatal development. Kinetic studies of the esterase activity revealed that hepatic Km values were similar to those of the lung, but renal Km values were about 3 times higher than those of the liver and lung. In each organ, no age-related changes in Km values were observed. However, all the Vmax values in each organ showed developmental increases. Therefore, the liver plays the most important role in hydrolysis of chloramphenicol succinate when the weight of the organ is taken into consideration.
T Yamakawa; S Itoh; S Onishi; K Isobe; A Hosoe; Y Nishimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  7     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1984  
Date Detail:
Created Date:  1984-07-16     Completed Date:  1984-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Chloramphenicol / analogs & derivatives*,  metabolism
Esterases / blood,  metabolism*
Fetus / metabolism
Gestational Age
Infant, Newborn
Kidney / enzymology*
Liver / enzymology*,  physiology
Lung / enzymology*
Middle Aged
Reg. No./Substance:
3544-94-3/chloramphenicol succinate; 56-75-7/Chloramphenicol; EC 3.1.-/Esterases

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