Document Detail

Developmental changes in free D-aspartic acid in the chicken embryo and in the neonatal rat.
MedLine Citation:
PMID:  2355797     Owner:  NLM     Status:  MEDLINE    
Free D-aspartic acid was measured in fertilized chicken eggs, chicken embryos, and neonatal rats. In each tissue examined a maximum value was found at a characteristic time of development. For the chicken embryo brain, the maximum was 9% D at 11 days of incubation; for the retina, 20% D at 13 days of incubation. In the neonatal rat, as in the chicken embryo, D-aspartic acid continued to increase in the retina after that in the brain and other tissues had begun to decline. The maximum, 29% D, was found 7 days after birth. Thus in two phylogenetically distant species, similar developmental patterns of D-aspartic acid change were observed. Some data on similarities between the D/L aspartic acid ratios of adult chicken and rat tissues are also reported. In addition, the total D-aspartic acid content of the egg, including the embryo, increased from 44 nmol at day 1 to 159 nmol at day 12, showing that release from a bound form or de novo synthesis is a continuing process during development.
A Neidle; D S Dunlop
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  46     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-20     Completed Date:  1990-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1517-22     Citation Subset:  IM    
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.
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MeSH Terms
Animals, Newborn
Aspartic Acid / blood,  metabolism*
Chick Embryo
Chromatography, High Pressure Liquid
Embryo, Mammalian / metabolism*
Embryo, Nonmammalian*
Organ Specificity
Rats, Inbred Strains
Reg. No./Substance:
56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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