Document Detail


Developmental changes in flow-wave propagation velocity in embryonic chick vascular system.
MedLine Citation:
PMID:  9321845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed flow-wave propagation velocity in the early embryonic vascular system and its responses to acute alterations in circulating blood volume. Two 20-MHz pulsed Doppler velocimeters were positioned along the arterial system in stage 18 (n = 12), 21 (n = 10), and 24 (n = 11) chick embryos. Distance between the two measurement sites was measured by video-microscopy. Phase velocity was calculated using Fourier transform up to the fourth harmonics. Wave-front velocity was also calculated by threshold technique. In a subset of embryos at stage 24 (n = 10), circulating blood volume was acutely altered to change stroke volume. Mean phase velocity increased from 42.9 +/- 3.3 to 95.8 +/- 7.5 cm/s from stage 18 to 24 (P < 0.05 by analysis of variance), whereas wave-front velocity increased from 52.8 +/- 2.4 to 72.2 +/- 5.2 cm/s. Stroke volume and mean aortic pressure paralleled the changes in mean phase velocity and wave-front velocity in normal development and in response to changes in circulating blood volume. Thus developmental changes in wave-propagation velocity were consistent with changes in the size of the vascular system, pressure range, and elastic properties of the arterial wall during systemic vasculogenesis in the embryo.
Authors:
M Yoshigi; J M Ettel; B B Keller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1523-9     Citation Subset:  IM    
Affiliation:
Strong Children's Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / embryology*,  physiology,  ultrasonography
Blood Flow Velocity*
Blood Pressure
Blood Volume
Cardiac Output
Chick Embryo
Fourier Analysis
Heart / embryology*,  physiology
Hemodynamics*
Stroke Volume
Time Factors
Ultrasonography, Doppler, Pulsed
Grant Support
ID/Acronym/Agency:
P50-HL-51498/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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