Document Detail

Developmental changes in dopamine modulation of the heart in the isopod crustacean Ligia exotica: reversal of chronotropic effect.
MedLine Citation:
PMID:  15459449     Owner:  NLM     Status:  MEDLINE    
Developmental changes in dopamine modulation of the heart were examined in the isopod crustacean Ligia exotica. The Ligia cardiac pacemaker is transferred from the myocardium to the cardiac ganglion during juvenile development and the heartbeat changes from myogenic to neurogenic. In the myogenic heart of early juveniles, dopamine affected the myocardium and caused a decrease in the frequency and an increase in the duration of the myocardial action potential, resulting in negative chronotropic (decrease in beat frequency) and positive inotropic (increase in contractile force) effects on the heart. Contrastingly, in the heart of immature adults just after juvenile development, dopamine caused effects of adult type, positive chronotropic and positive inotropic effects on the heart affecting the cardiac ganglion and myocardium. During the middle and late juvenile stages, dopamine caused individually a negative or a positive chronotropic effect on the heart. These results suggest that the chronotropic effect of dopamine on the Ligia heart is reversed from negative to positive in association with the cardiac pacemaker transfer from the myocardium to the cardiac ganglion during juvenile development.
Hiroshi Yamagishi; Hiroshi Miyamoto; Akira Sakurai
Related Documents :
2441369 - Computer modeling of ddd pacemakers for use in prophylaxis of junctional reentry tachyc...
6630609 - Electrosurgery and cardiac pacemakers.
25377999 - Left atrium dilatation and multiple vascular territory strokes.
25303079 - The impact of syntax score of non-infarct-related artery on long- term outcome among pa...
7683809 - Voltage dip in pacemaker battery supply: a new cause of pacemaker mediated tachycardia.
2909559 - Combined automatic implantable cardioverter-defibrillator and pacemaker systems: implan...
12595849 - Response of the right ventricle to acute pulmonary vasodilation predicts the outcome in...
17214619 - Correlation of the myocardial performance index with conventional echocardiographic ind...
10600869 - Pharmacological manipulation of ins(1,4,5)p3 signaling mimics preconditioning in rabbit...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zoological science     Volume:  21     ISSN:  0289-0003     ISO Abbreviation:  Zool. Sci.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702287     Medline TA:  Zoolog Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  917-22     Citation Subset:  IM    
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials
Cardiotonic Agents / pharmacology*
Dopamine / pharmacology*
Evoked Potentials
Ganglia, Invertebrate / drug effects*,  growth & development,  physiology
Heart / drug effects,  embryology,  growth & development
Heart Conduction System / drug effects,  growth & development,  physiology
Isopoda / drug effects,  embryology,  growth & development*
Myocardial Contraction / drug effects*,  physiology
Myocardium / metabolism
Reg. No./Substance:
0/Cardiotonic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structural analysis and identification of novel isoforms of the circadian clock gene period in the s...
Next Document:  Development and swimming behavior of Medaka fry in a spaceflight aboard the Space Shuttle Columbia (...