Document Detail


Developmental changes in dopamine modulation of the heart in the isopod crustacean Ligia exotica: reversal of chronotropic effect.
MedLine Citation:
PMID:  15459449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Developmental changes in dopamine modulation of the heart were examined in the isopod crustacean Ligia exotica. The Ligia cardiac pacemaker is transferred from the myocardium to the cardiac ganglion during juvenile development and the heartbeat changes from myogenic to neurogenic. In the myogenic heart of early juveniles, dopamine affected the myocardium and caused a decrease in the frequency and an increase in the duration of the myocardial action potential, resulting in negative chronotropic (decrease in beat frequency) and positive inotropic (increase in contractile force) effects on the heart. Contrastingly, in the heart of immature adults just after juvenile development, dopamine caused effects of adult type, positive chronotropic and positive inotropic effects on the heart affecting the cardiac ganglion and myocardium. During the middle and late juvenile stages, dopamine caused individually a negative or a positive chronotropic effect on the heart. These results suggest that the chronotropic effect of dopamine on the Ligia heart is reversed from negative to positive in association with the cardiac pacemaker transfer from the myocardium to the cardiac ganglion during juvenile development.
Authors:
Hiroshi Yamagishi; Hiroshi Miyamoto; Akira Sakurai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zoological science     Volume:  21     ISSN:  0289-0003     ISO Abbreviation:  Zool. Sci.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702287     Medline TA:  Zoolog Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  917-22     Citation Subset:  IM    
Affiliation:
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan. yamagashi@biol.tsukuba.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Cardiotonic Agents / pharmacology*
Dopamine / pharmacology*
Electrophysiology
Evoked Potentials
Female
Ganglia, Invertebrate / drug effects*,  growth & development,  physiology
Heart / drug effects,  embryology,  growth & development
Heart Conduction System / drug effects,  growth & development,  physiology
Isopoda / drug effects,  embryology,  growth & development*
Male
Myocardial Contraction / drug effects*,  physiology
Myocardium / metabolism
Chemical
Reg. No./Substance:
0/Cardiotonic Agents

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