Document Detail


Developmental changes in the content of dopamine in the olfactory bulb of the European eel (Anguilla anguilla).
MedLine Citation:
PMID:  8084534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentrations of dopamine (DA) and of its major metabolite, dihydroxyphenylacetic acid (DOPAC), were measured in discrete areas of the eel brain. To investigate the developmental changes in the content of DA and DOPAC, the assays were performed in yellow eels (i.e. at the feeding stage) and silver eels (i.e. at the migratory stage). DA and DOPAC were unevenly distributed in the eel brain. In yellow eels, the concentration of DA was highest (16-19 pmol/mg protein) in the olfactory bulb (OB), mesencephalic tectum-diencephalon (MT-D) and medulla oblongata (MO) and lowest in the cerebellum (CB, 1 pmol/mg protein), whereas intermediate values were measured in the telencephalon (TE; 10 pmol/mg protein). The metabolic rate of DA, as reflected by the DOPAC/DA ratio, was highest in the OB and CB, with progressively smaller values being observed in the TE, MT-D, and MO. A significant increase in the concentrations of DA (+80%) and DOPAC (+122%) was observed in the OB of silver eels compared with yellow eels, whereas no significant differences were detected in the concentrations of DA and DOPAC in the other brain areas as a function of the developmental stage. The results are discussed in terms of the possible involvement of environmental, behavioral and developmental factors.
Authors:
O Giorgi; A M Deiana; S Salvadori; D Lecca; M G Corda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  172     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-11     Completed Date:  1994-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Affiliation:
Department of Toxicology, University of Cagliari, Italy.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Anguilla / metabolism*
Animals
Brain Chemistry / physiology
Dopamine / metabolism*
Olfactory Bulb / growth & development*,  metabolism*
Chemical
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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