| Developmental changes of free amino acid concentrations in fetal fluids of pigs. | |
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MedLine Citation:
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PMID: 7472667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free amino acid concentrations were determined in amniotic and allantoic fluids and in fetal and maternal uterine plasma of pigs during gestation. Glycine and glutamine were the most abundant free amino acids in maternal uterine arterial and fetal umbilical venous plasma, respectively. Plasma fetal/maternal ratios were remarkably < 1 for glycine, > 2 for glutamine and = 1 for total free alpha-amino acids. Glutamine was the most abundant free amino acid in amniotic fluid during the first 3 mo of gestation. The concentrations of most amniotic fluid amino acids progressively decreased with increasing gestational age from 45 to 110 d. Glycine was the most predominant amino acid in allantoic fluid on d 30 of gestation but decreased on d 45 and 60 of gestation. This decrease in allantoic fluid glycine coincided with a marked increase in concentrations of both ornithine and arginine, which accounted for 34-36% of total free alpha-amino acids in allantoic fluid. Such an abundance of ornithine and arginine in allantoic fluid has not been reported for any other biological fluid. On d 90 and 110 of gestation, glycine again became the most abundant amino acid in allantoic fluid, or 47 and 29% of total free alpha-amino acids, respectively. Urea concentrations in amniotic and allantoic fluids progressively increased during the second half of pregnancy, indicating enhanced fetal protein metabolism. Our results demonstrate the abundance of glutamine in fetal plasma, the unusual abundance of ornithine, arginine and glycine in allantoic fluid and developmental changes in plasma fetal/maternal ratios of amino acids.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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G Wu; F W Bazer; W Tou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 125 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-12-19 Completed Date: 1995-12-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2859-68 Citation Subset: IM |
Affiliation:
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Department of Animal Science, Texas A & M University, College Station 77843-2471, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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blood,
metabolism Allantois / chemistry* Amino Acids / analysis*, blood Ammonia / analysis, blood Amniotic Fluid / chemistry* Animals Arginine / analysis, blood Female Fetal Blood / chemistry Gestational Age* Glutamine / analysis, blood Glycine / analysis, blood Male Ornithine / analysis, blood Placenta / chemistry Pregnancy Swine / blood, embryology, metabolism* Urea / analysis, blood Uterus / blood supply |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 56-40-6/Glycine; 56-85-9/Glutamine; 57-13-6/Urea; 7006-33-9/Ornithine; 74-79-3/Arginine; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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