| Developmental changes of cortical and cerebellar motor control: a clinical positron emission tomography study with children and adults. | |
| | |
MedLine Citation:
|
PMID: 9853648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Functional neuroimaging data regarding the development of motor organization in normal children and adolescents are virtually unavailable because of ethical concerns. As an alternative approach, we studied child and adult lesion patients, focusing on movement of the hand ipsilateral to the lesion and on brain activations in the contralesional hemisphere. [15O]-water positron emission tomography was performed during rest and sequential finger-thumb tapping in 10 children (aged 6 to 14 years) and 15 adults (aged 18 to 74 years) with unilateral lesion. We expected more distinct activation/deactivation patterns during movement in adults than in children. While there were no group differences in activation of primary and secondary motor cortices, deactivations in nonmotor cortex were significantly more pronounced in adults than in children. This indirectly supports our hypothesis of developmental focalization of cerebral motor control. Activations in the cerebellum and vermis were significantly stronger in the adults than in the children, possibly reflecting normal developmental patterns. |
| | |
Authors:
|
R A Müller; R D Rothermel; M E Behen; O Muzik; T J Mangner; H T Chugani |
Related Documents
:
|
8885948 - Early identification of cerebral palsy using a profile of abnormal motor patterns. 20673078 - Improving gross motor function and postural control with hippotherapy in children with ... 2449078 - Motor and cognitive deficits after intrapartum asphyxia in the mature fetus. 11006808 - Reliability and validity of a parent questionnaire on childhood motor skills. 1427448 - Normal values of total reticulocytes and reticulocyte subsets in children and young adu... 17652768 - Prevention of ifosfamide nephrotoxicity by n-acetylcysteine: clinical pharmacokinetic c... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of child neurology Volume: 13 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1999-03-05 Completed Date: 1999-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 550-6 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Wayne State University Medical School, Detroit, MI, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aging / physiology* Brain Neoplasms / physiopathology Cerebellum / physiology*, radionuclide imaging Cerebral Cortex / physiology*, radionuclide imaging Cerebrovascular Circulation Child Epilepsy / physiopathology Female Fingers / physiology Humans Male Middle Aged Motor Skills / physiology* Movement / physiology Tomography, Emission-Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbama...
Next Document: Beta-interferon plus inosiplex in the treatment of subacute sclerosing panencephalitis.