Document Detail

Developmental changes of amniotic fluid alpha-fetoprotein subfractions in early gestation.
MedLine Citation:
PMID:  6190415     Owner:  NLM     Status:  MEDLINE    
Using both concanavalin A crossed-line affinity immunoelectrophoresis and lentil lectin crossed-line affinity immunoelectrophoresis, developmental changes of alpha-fetoprotein (AFP) subfractions were studied in 11 samples of human amniotic fluid obtained between 43 and 121 days of gestation. In the amniotic fluid at 43 or 48 days of gestation, only subfractions produced by the yolk sac were evident. The initial appearance of the subfractions produced by the fetal liver was first detected at 51 days of gestation. Percentages of liver-originated subfractions rose rapidly with gestational age and reached a level of 50% at 54 days of gestation. The subfractions produced by the yolk sac disappeared from the amniotic fluid at 121 days of gestation. These findings suggest that, in early gestation, the yolk sac is mainly responsible for the fetal AFP synthesis and that initiation of AFP production by the fetal liver takes place between 48 and 51 days of gestation. In the present study, attention was also given to the origin of four subfractions separated by the lentil lectin crossed-line affinity immunoelectrophoresis.
T Ishiguro; H Sakaguchi; I Sugitachi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction     Volume:  3     ISSN:  0271-7352     ISO Abbreviation:  Am J Reprod Immunol     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111069     Medline TA:  Am J Reprod Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis*
Concanavalin A / diagnostic use
Gestational Age
Immunoelectrophoresis, Two-Dimensional
Plant Lectins*
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Lectins; 0/Plant Lectins; 0/alpha-Fetoproteins; 0/lentil lectin; 11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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