Document Detail


Developmental changes of aldehyde dehydrogenase isozymes in human livers: mitochondrial ALDH2 isozyme is expressed in fetal livers.
MedLine Citation:
PMID:  2373201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous reports suggested that the major cytosolic aldehyde dehydrogenase (ALDH1) was present in fetal and infant livers, but the major mitochondrial isozyme (ALDH2) was absent or severely diminished. Re-examination by means of starch gel electrophoresis followed by enzyme activity staining, and by means of dot blot immuno-hybridization of liver samples with known genotypes of the ALDH2 locus, indicated that both ALDH1 and ALDH2 genes are expressed in fetal and infant livers. In addition, ALDH4 isozyme was also observed. The results imply that a fetus with the 'usual' homozygous ALDH1(2)/ALDH1(2) genotype, but not one with the atypical ALDH1(2)/ALDH2(2) or ALDH2(2)/ALDH2(2), is capable of detoxifying acetaldehyde transferred from the mother.
Authors:
A Yoshida; A Shibuya; V Davé; M Nakayama; A Hayashi
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experientia     Volume:  46     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-30     Completed Date:  1990-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  747-50     Citation Subset:  IM    
Affiliation:
Department of Biochemical Genetics, Beckman Research Institute, City of Hope, Duarte, California 91010.
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MeSH Terms
Descriptor/Qualifier:
Aldehyde Dehydrogenase / metabolism*
Electrophoresis, Starch Gel
Humans
Immunoblotting
Isoenzymes / metabolism*
Liver / embryology*,  enzymology
Grant Support
ID/Acronym/Agency:
AA05763/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.2.1.3/Aldehyde Dehydrogenase

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