Document Detail

Developmental changes of (3)H-labelled mu-opioid receptors in brainstems of intra-uterine growth-restricted rats.
MedLine Citation:
PMID:  11248355     Owner:  NLM     Status:  MEDLINE    
The opioid mu-system is involved in brainstem-mediated respiratory control. Infants with intra-uterine growth restriction (IUGR) have more respiratory disorders in the early postnatal period. Using [(3)H]DAGO, a mu-selective ligand, and a computer-based image analysis of autoradiography, we compared the ontogeny and distribution of mu-opioid binding sites in the brainstem of IUGR and control rats in utero (E21), at birth (P0) and on postnatal days 1 (P1), P7, P10, P14 and P21. The ontogeny pattern was found to be similar in both groups. The density of the binding sites, which was low in E21, increased at P0, slightly declined at P1 and remained relatively constant thereafter. The distribution of DAGO-binding sites, also similar in both groups, was heterogeneous and was much denser in the dorsal areas of medulla and pons. In particular, binding sites were highly concentrated in nuclei involved in the cardio-respiratory function. However, DAGO-binding density was higher at all ages (except for P0 and P1) in IUGR than in control rats. Taken together, these results give at least a partial explanation for the effects of IUGR which lowers the Apgar score at birth and raises the incidence of respiratory disorders in infants.
J Liu; C Dong; L Cazin; M Clabaut; I Dubuc; J Costentin; A Coquerel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  126     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Laboratory of Fetal-Maternal Pathophysiology, Faculty of Sciences, University of Rouen, 76821 Mont-Saint-Aignan, France.
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MeSH Terms
Aging / metabolism*
Animals, Newborn
Brain Stem / embryology,  metabolism*
Cell Count
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / metabolism
Fetal Growth Retardation / metabolism*,  pathology
Image Processing, Computer-Assisted
Medulla Oblongata / embryology,  metabolism
Organ Specificity
Pons / embryology,  metabolism
Receptors, Opioid, mu / metabolism*
Solitary Nucleus / embryology,  metabolism
Reg. No./Substance:
0/Receptors, Opioid, mu; 10028-17-8/Tritium; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-

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