| Developmental cardiac metabolism in health and disease. | |
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MedLine Citation:
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PMID: 2678017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac metabolism changes in response to oxygen and substrate availability during development. The fetus is relatively more dependent on anaerobic glycolysis, using glucose as its major substrate during hypoxia, lactate when well-oxygenated. The mature heart is almost exclusively aerobic, with nonesterified fatty acids as the predominant substrate. During hypoxia and ischemia, shifting the heart to carbohydrate metabolism has oxygen-sparing effects. Blocking lipolysis or carnitine palmityl transferase activity prevents accumulation of potentially toxic long-chain esters during hypoxia/ischemia, thereby reducing the risk of electrophysiologic disturbance and membrane disruption. Knowledge of developmental cardiac metabolism may aid in the development of therapeutic strategies to preserve the myocardium during hypoxia and ischemia. |
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Authors:
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M E Tripp |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric cardiology Volume: 10 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-07 Completed Date: 1989-11-07 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 150-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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drug therapy,
metabolism,
physiopathology Carbohydrates / therapeutic use Carnitine O-Palmitoyltransferase / antagonists & inhibitors Enzyme Activation Fetal Heart / metabolism* Heart / growth & development Humans Ischemia / drug therapy, metabolism, physiopathology Lipolysis Myocardium / metabolism* Oxygen Consumption Pyruvate Dehydrogenase Complex / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates; 0/Pyruvate Dehydrogenase Complex; EC 2.3.1.21/Carnitine O-Palmitoyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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