| Developmental and behavioral consequences of prenatal fluoxetine. | |
| | |
MedLine Citation:
|
PMID: 17077648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Fluoxetine, a selective serotonin reuptake inhibitor, is the most commonly prescribed antidepressant drug for pregnant women. Studies regarding the teratogenic effect of fluoxetine on human and animal models are mainly concerned with structural malformation (congenital anomalies). Aim: Hence, the present study was planned to evaluate the postnatal behavioral effects of fluoxetine on albino rats. METHODS: Three groups of female rats received either distilled water or doses of fluoxetine 8 and 12 mg/kg orally from the 6th to the 20th day of pregnancy. Weaning of the pups was done on the 21st day followed by a battery of behavioral tests to assess for any behavioral effect. The tests included negative geotaxis, open field exploration, rota-rod test, elevated plus maze and passive avoidance test. RESULTS: In the present study there was no change in the gestational length of pregnancy, no premature birth or miscarriage during pregnancy. A high dose of in utero fluoxetine resulted in a decrease in birth weight of the offspring and also reduced weight gain during the preweaning period. No major congenital abnormalities were observed in the offspring exposed to fluoxetine. Prenatal fluoxetine exposure at high dose caused an initial transient delay in motor development and this poor motor activity was transient and not permanent. However, prenatal exposure to fluoxetine at a higher dose showed a favorable effect on learning and memory in water maze and passive avoidance tests. CONCLUSIONS: From the present study, it may be concluded that prenatal fluoxetine causes a transient delay in motor development but does not adversely affect the postnatal behavioral consequences. |
| | |
Authors:
|
K L Bairy; S Madhyastha; K P Ashok; Indira Bairy; S Malini |
Related Documents
:
|
3893468 - Blood acetaldehyde response to ethanol ingestion during the reproductive cycle of the f... 15609968 - Al-isopropoxydiisobutylalane: a study of the effect of solvent on the rate and stereose... 22372588 - Medical responsibility in the operating room: the example of an amniotic fluid embolism. 8947608 - Bronchial responsiveness and inflammation in guinea-pigs exposed to toluene diisocyanat... 20629488 - Two-stage transvaginal cervical length screening for preterm birth in twin pregnancies. 21876088 - Reference intervals for fetal ear length between 19 and 24 weeks of pregnancy on 3-dime... |
Publication Detail:
|
Type: Journal Article Date: 2006-10-08 |
Journal Detail:
|
Title: Pharmacology Volume: 79 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 2007 |
Date Detail:
|
Created Date: 2006-12-28 Completed Date: 2007-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 1-11 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2007 S. Karger AG, Basel. |
Affiliation:
|
Department of Pharmacology, Kasturba Medical College, Manipal, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Animals, Newborn Behavior, Animal / drug effects*, physiology Birth Weight / drug effects Dose-Response Relationship, Drug Exploratory Behavior / drug effects Female Fluoxetine / administration & dosage, pharmacology* Head Movements / drug effects Litter Size / drug effects Maze Learning / drug effects Motor Activity / drug effects, physiology Pregnancy Prenatal Exposure Delayed Effects* Psychomotor Performance / drug effects Rats Rats, Wistar Serotonin Uptake Inhibitors / administration & dosage, pharmacology Sex Factors Time Factors Tooth Eruption / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Uptake Inhibitors; 54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Airway smooth muscle relaxations induced by dipyrone.
Next Document: Direct anatomical localization of the subthalamic nucleus on CT with comparison to Schaltenbrand-Wah...