| Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. | |
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MedLine Citation:
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PMID: 19741259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The upper airway serves three important functions: respiration, swallowing, and speech. During development it undergoes significant structural and functional changes that affect its size, shape, and mechanical properties. Abnormalities of the upper airway require prompt attention, because these often alter ventilatory patterns and gas exchange, particularly during sleep when upper airway motor tone and ventilatory drive are diminished. Recognizing the relationship of early life events to lung health and disease, the National Heart, Lung, and Blood Institute (NHLBI), with cofunding from the Office of Rare Diseases (ORD), convened a workshop of extramural experts, from many disciplines. The objective of the workshop was: (1) to review the state of science in pediatric upper airway disorders; (2) to make recommendations to the Institute to fill knowledge gaps; (3) to prioritize new research directions; and (4) to capitalize on scientific opportunities. This report provides recommendations that could facilitate translation of basic research findings into practice to better diagnose, treat, and prevent airway compromise in children. |
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Authors:
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Carole L Marcus; Richard J H Smith; Leila A Mankarious; Raanan Arens; Gordon S Mitchell; Ravindhra G Elluru; Vito Forte; Steven Goudy; Ethylin W Jabs; Alex A Kane; Eliot Katz; David Paydarfar; Kevin Pereira; Roger H Reeves; Joan T Richtsmeier; Ramon L Ruiz; Bradley T Thach; David E Tunkel; Jeffrey A Whitsett; David Wootton; Carol J Blaisdell |
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Publication Detail:
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Type: Congresses; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Proceedings of the American Thoracic Society Volume: 6 ISSN: 1943-5665 ISO Abbreviation: Proc Am Thorac Soc Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-10 Completed Date: 2010-01-05 Revised Date: 2012-01-26 |
Medline Journal Info:
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Nlm Unique ID: 101203596 Medline TA: Proc Am Thorac Soc Country: United States |
Other Details:
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Languages: eng Pagination: 513-20 Citation Subset: IM |
Affiliation:
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Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomedical Research / organization & administration* Diagnostic Imaging Humans Models, Animal National Institutes of Health (U.S.) Pediatrics* Respiratory System / growth & development* Respiratory System Abnormalities / diagnosis, physiopathology*, therapy Respiratory Tract Diseases / congenital*, diagnosis, physiopathology, prevention & control United States |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL095580-03/HL/NHLBI NIH HHS; R01 HL095580-04/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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