Document Detail

Developmental aspects of type II lissencephaly. Comparative study of dysplastic lesions in fetal and post-natal brains.
MedLine Citation:
PMID:  7709734     Owner:  NLM     Status:  MEDLINE    
We report neuropathological studies of five cases of type II lissencephaly from three fetuses and two infants. This comparative study allowed us to determine the developmental course of the cerebral lesions. Two distinct developmental events seem to generate this type of brain malformation: firstly, an early disturbance in cortex formation, which results both from a disorder of radial migration and a pial barrier disruption; secondly, a late perturbation of cerebral surface organization, resulting in fusion of the cerebral surface. All these features can be related to a primitive meningeal pathology, and more generally, to a neurocristopathy. Accordingly to our observations, this brain malformation appears during both migrational and post-migrational stages and may be considered more like a polymicrogyria than a lissencephaly.
A Gelot; T Billette de Villemeur; C Bordarier; M M Ruchoux; C Moraine; G Ponsot
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  89     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-10     Completed Date:  1995-05-10     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  72-84     Citation Subset:  IM    
Unité de neuropathologie, INSERM U 29, Hôpital St Vincent de Paul, Paris, France.
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MeSH Terms
Abnormalities, Multiple / embryology,  etiology,  pathology
Brain / abnormalities*,  embryology,  pathology*
Cerebellum / embryology,  pathology*,  physiopathology
Cerebral Cortex / embryology,  pathology,  physiopathology
Fetal Diseases / embryology,  etiology,  pathology*
Meninges / pathology
Neurons / pathology

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