Document Detail


Developmental aspects of the monoamine-degrading enzyme monoamine oxidase.
MedLine Citation:
PMID:  1306808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the rat heart, monoamine oxidase (MAO)-B activity was shown to predominate in 2- to 3-week-old animals, whereas MAO-A activity was reported to be very low in newborn rats and to increase considerably with age until it predominates. These results are in contrast with those found in the mouse heart, where an age-dependent increase in MAO-B activity with no changes in 5-hydroxytryptamine deaminating activity was found to occur. There is evidence that the adult values of MAO activity are reached early in development in rat kidney and liver. In the rat lung the adult values of MAO-A activity are reached by day 40, whereas MAO-B activity is still increasing by day 80. Important differences have been reported in the developmental pattern of the two forms of MAO in the rat and mouse brain, with a decrease in the MAO-A/MAO-B ratio during postnatal development. In the human brain, the ontogenetic development of MAO-A and MAO-B appears to parallel that observed in the rodent brain. It is worth noting that most of the available data have to be considered with reservation owing to many methodological problems. Further studies are clearly needed to get reliable information on the ontogenesis of MAO in mammalian tissues.
Authors:
M Strolin Benedetti; P Dostert; K F Tipton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  18     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1992  
Date Detail:
Created Date:  1993-08-13     Completed Date:  1993-08-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  191-200     Citation Subset:  IM    
Affiliation:
Farmitalia Carlo Erba, R&D-Erbamont Group, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / enzymology,  growth & development
Female
Heart / growth & development
Monoamine Oxidase / metabolism*
Myocardium / enzymology
Pregnancy
Rats
Chemical
Reg. No./Substance:
EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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