Document Detail


Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport.
MedLine Citation:
PMID:  12900088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammalian central nervous system (CNS) is characterized by the blood-brain barrier (BBB), a restrictive barrier endowed with the maintenance of homeostatic control of an optimal milieu within the brain. Whereas in tissues other than the CNS, concentrations of various metabolites (amino acids, K+) can undergo frequent fluctuations, the CNS must keep rigorous control over the extracellular cerebral fluid composition, preventing the mirroring of transient fluctuations in blood, because abrupt changes in these metabolites can translate to aberrant CNS function. The BBB is a specialized structure accomplished by individual endothelial cells that are continuously linked by tight junctions. This brief review will address pertinent issues to development of the BBB. Particular emphasis will be directed at the role of astrocytes in the induction and maintenance of the restrictive properties of this barrier, and the utility of in vitro culture models in surveying transport kinetics, exemplified by recent studies with the pesticide, chlorpyrifos.
Authors:
Jian Yang; Michael Aschner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neurotoxicology     Volume:  24     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-05     Completed Date:  2003-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  741-5     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / drug effects,  metabolism
Biological Transport / drug effects,  physiology
Blood-Brain Barrier / drug effects,  physiology*
Brain / drug effects,  growth & development,  metabolism
Chlorpyrifos / pharmacokinetics*
Endothelium, Vascular / growth & development*,  metabolism*
Humans
Grant Support
ID/Acronym/Agency:
ES 010563/ES/NIEHS NIH HHS; ES 07331/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
2921-88-2/Chlorpyrifos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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