Document Detail

Developmental alterations of the prefrontal cerebral cortex in sudden unexplained perinatal and infant deaths.
MedLine Citation:
PMID:  19196205     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the developmental patterns of the human prefrontal cortex involved in breathing control in a wide cohort of fetal and infant death victims, aged from the 22(nd) gestational week to 10 months of life, and to evaluate whether morpho-functional disorders are present in this specific cortical area in victims of sudden unexplained death. A further aim was to determine whether prenatal absorption of nicotine could also affect the maturational processes of the prefrontal cortex. A pronounced radial organization of the cerebral wall was evident from the 26(th) gestational week. By 36 gestational weeks this columnar structure disappeared, coinciding with the formation of a laminar cyto-architecture. The mature cortex, observable from the 4(th) month of life, was organized horizontally into six laminae. In 33% of the sudden death victims the prefrontal cortex showed morphological alterations with anomalous laminar patterns and delayed neuronal maturation. A significant correlation with prenatal cigarette exposure was found.
Anna Maria Lavezzi; Maria Mauri; Donatella Mecchia; Luigi Matturri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  37     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-23     Completed Date:  2010-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  297-303     Citation Subset:  IM    
Lino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, University of Milan, Italy.
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MeSH Terms
Fetal Death*
Fetal Development*
Infant, Newborn
Prefrontal Cortex / growth & development*,  pathology*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Sudden Infant Death*
Tobacco Smoke Pollution
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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