Document Detail


Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder.
MedLine Citation:
PMID:  21871375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal-striatal-thalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) and emotion processing (ventral medial frontal cortex) follow unique maturational trajectories, and altered connectivity within distinct loops may be differentially associated with OCD at specific stages of development.
METHOD: Altered development of striatal and thalamic connectivity to medial frontal cortex was tested in 60 OCD patients compared with 61 healthy control subjects at child, adolescent, and adult stages of development, using resting-state functional connectivity MRI.
RESULTS: OCD in the youngest patients was associated with reduced connectivity of dorsal striatum and medial dorsal thalamus to rostral and dorsal anterior cingulate cortex, respectively. Increased connectivity of dorsal striatum to ventral medial frontal cortex was observed in patients at all developmental stages. In child patients, reduced connectivity between dorsal striatum and rostral anterior cingulate cortex correlated with OCD severity.
CONCLUSIONS: Frontal-striatal-thalamic loops involved in cognitive control are hypoconnected in young patients near illness onset, whereas loops implicated in emotion processing are hyperconnected throughout the illness.
Authors:
Kate Dimond Fitzgerald; Robert C Welsh; Emily R Stern; Mike Angstadt; Gregory L Hanna; James L Abelson; Stephan F Taylor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-31
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  50     ISSN:  1527-5418     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-01-05     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  938-948.e3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Female
Frontal Lobe / physiopathology*
Humans
Magnetic Resonance Imaging
Male
Neostriatum / physiopathology*
Neural Pathways / growth & development,  physiopathology*
Obsessive-Compulsive Disorder / diagnosis,  physiopathology*
Oxygen / blood
Thalamus / physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
F32 MH082573/MH/NIMH NIH HHS; K23 MH082176/MH/NIMH NIH HHS; K23 MH082176-03/MH/NIMH NIH HHS; K23MH082176/MH/NIMH NIH HHS; R01 MH071821/MH/NIMH NIH HHS; R01 NS052514/NS/NINDS NIH HHS; R01-NS052514/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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