| Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder. | |
| | |
MedLine Citation:
|
PMID: 21871375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal-striatal-thalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) and emotion processing (ventral medial frontal cortex) follow unique maturational trajectories, and altered connectivity within distinct loops may be differentially associated with OCD at specific stages of development. METHOD: Altered development of striatal and thalamic connectivity to medial frontal cortex was tested in 60 OCD patients compared with 61 healthy control subjects at child, adolescent, and adult stages of development, using resting-state functional connectivity MRI. RESULTS: OCD in the youngest patients was associated with reduced connectivity of dorsal striatum and medial dorsal thalamus to rostral and dorsal anterior cingulate cortex, respectively. Increased connectivity of dorsal striatum to ventral medial frontal cortex was observed in patients at all developmental stages. In child patients, reduced connectivity between dorsal striatum and rostral anterior cingulate cortex correlated with OCD severity. CONCLUSIONS: Frontal-striatal-thalamic loops involved in cognitive control are hypoconnected in young patients near illness onset, whereas loops implicated in emotion processing are hyperconnected throughout the illness. |
| | |
Authors:
|
Kate Dimond Fitzgerald; Robert C Welsh; Emily R Stern; Mike Angstadt; Gregory L Hanna; James L Abelson; Stephan F Taylor |
Related Documents
:
|
21855055 - Glutamatergic plasticity in medial prefrontal cortex and ventral tegmental area followi... 20227315 - Ammonia toxicity to the brain: effects on creatine metabolism and transport and protect... 18471905 - Barriers in the brain: a renaissance? 21642035 - Integrated multiscale modeling of the nervous system: predicting changes in hippocampal... 19335885 - Immunohistochemical study of prp(sc) distribution in neural and extraneural tissues of ... 3232855 - Topographic organization of the auditory thalamocortical system in the albino rat. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-07-31 |
Journal Detail:
|
Title: Journal of the American Academy of Child and Adolescent Psychiatry Volume: 50 ISSN: 1527-5418 ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-29 Completed Date: 2012-01-05 Revised Date: 2012-09-27 |
Medline Journal Info:
|
Nlm Unique ID: 8704565 Medline TA: J Am Acad Child Adolesc Psychiatry Country: United States |
Other Details:
|
Languages: eng Pagination: 938-948.e3 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
University of Michigan Medical School, MI, USA. krd@umich.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Child Female Frontal Lobe / physiopathology* Humans Magnetic Resonance Imaging Male Neostriatum / physiopathology* Neural Pathways / growth & development, physiopathology* Obsessive-Compulsive Disorder / diagnosis, physiopathology* Oxygen / blood Thalamus / physiopathology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
F32 MH082573/MH/NIMH NIH HHS; K23 MH082176-03/MH/NIMH NIH HHS; K23MH082176/MH/NIMH NIH HHS; R01 MH071821/MH/NIMH NIH HHS; R01-NS052514/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of mental health and substance use problems and criminogenic risk on outcomes in serious j...
Next Document: Tubercular osteomyelitis of the second metatarsal: a case report.