Document Detail


Developmental twin study of attention problems: high heritabilities throughout development.
MedLine Citation:
PMID:  23303526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: The genetic and environmental link between attention-deficit/hyperactivity disorder in childhood and the adult manifestation of the disorder is poorly understood because of a lack of longitudinal studies with cross-informant data.
OBJECTIVE: To explore the relative contribution of genetic and environmental influences on symptoms of attention problems from childhood to early adulthood.
DESIGN: Analysis was conducted using longitudinal structural equation modeling with multiple informants.
SETTING: The Swedish Twin Study of Child and Adolescent Development.
PARTICIPANTS: One thousand four hundred eighty twin pairs were prospectively followed up from childhood to young adulthood.
MAIN OUTCOME MEASURES: Symptoms were obtained using parent and self-ratings of the Attention Problems Scale at ages 8 to 9, 13 to 14, 16 to 17, and 19 to 20 years.
RESULTS: The best-fitting model revealed high heritability of attention problems as indexed by parent and self-ratings from childhood to early adulthood (h² = 0.77-0.82). Genetic effects operating at age 8 to 9 years continued, explaining 41%, 34%, and 24% of the total variance at ages 13 to 14, 16 to 17, and 19 to 20 years. Moreover, new sets of genetic risk factors emerged at ages 13 to 14, 16 to 17, and 19 to 20 years.
CONCLUSIONS: The shared view of self- and informant-rated attention problems is highly heritable in childhood, adolescence, and early adulthood, suggesting that the previous reports of low heritability for attention-deficit/hyperactivity disorder in adults are best explained by rater effects. Both genetic stability and genetic innovation were present throughout this developmental stage, suggesting that attention problems are a developmentally complex phenotype characterized by both continuity and change across the life span.
Authors:
Zheng Chang; Paul Lichtenstein; Philip J Asherson; Henrik Larsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  JAMA psychiatry     Volume:  70     ISSN:  2168-6238     ISO Abbreviation:  JAMA Psychiatry     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-07     Completed Date:  2013-05-02     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101589550     Medline TA:  JAMA Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adolescent Development
Age Factors
Attention Deficit Disorder with Hyperactivity* / etiology,  genetics
Child
Child Development
Female
Gene-Environment Interaction
Humans
Longitudinal Studies
Male
Models, Genetic
Phenotype
Sex Factors
Twins / genetics*,  psychology
Twins, Dizygotic / genetics,  psychology
Twins, Monozygotic / genetics,  psychology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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