Document Detail


Developmental and stress-induced remodeling of cell–cell communication in the adrenal medullary tissue.
MedLine Citation:
PMID:  21061165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The adrenal medullary tissue contributes to maintain body homeostasis in reaction to stressful environmental changes via the release of catecholamines into the blood circulation in response to splanchnic nerve activation. Accordingly, chromaffin cell stimulus-secretion coupling undergoes temporally restricted periods of anatomo- functional remodeling in response to prevailing hormonal requirements of the organism. The postnatal development of the adrenal medulla and response to stress are remarkable physiological situations in which the stimulus- secretion coupling is critically affected. Catecholamine secretion from rat chromaffin cells is under a dual control involving an incoming initial command arising from the sympathetic nervous system that releases acetylcholine at the splanchnic nerve terminal-chromaffin cell synapses and a local gap junction-mediated intercellular communication. Interestingly, these two communication pathways are functionally interconnected within the gland and exhibit coordinated plasticity mechanisms. This article reviews the physiological and molecular evidence that the adrenal medullary tissue displays anatomical and functional adaptative remodeling of cell–cell communications upon physiological (postnatal development) and/or physiopathological (stress) situations associated with specific needs in circulating catecholamine levels.
Authors:
Nathalie C Guérineau; Michel G Desarménien
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  30     ISSN:  1573-6830     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-04-14     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1425-31     Citation Subset:  IM    
Affiliation:
Department of Integrated Neurovascular Biology, CNRS UMR6214, Inserm U771, University of Angers, UFR Sciences Médicales, 1 rue Haute de Reculée, 49045 Angers Cedex 01, France. nathalie.guerineau@univ-angers.fr
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adrenal Medulla / cytology*,  growth & development*
Animals
Cell Communication*
Gap Junctions / metabolism
Humans
Stress, Physiological*
Synaptic Transmission
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