Document Detail


Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms.
MedLine Citation:
PMID:  22846496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recurrent apnea with intermittent hypoxia (IH) is a major clinical problem in infants born preterm. Carotid body chemo-reflex and catecholamine secretion from adrenal medullary chromaffin cells (AMC) are important for maintenance of cardio-respiratory homeostasis during hypoxia. This article highlights studies on the effects of IH on O(2) sensing by the carotid body and AMC in neonatal rodents. Neonatal IH augments hypoxia-evoked carotid body sensory excitation and catecholamine secretion from AMC which are mediated by reactive oxygen species (ROS)-dependent recruitment of endothelin-1 and Ca(2+) signaling, respectively. The effects of neonatal IH persist into adulthood. Evidence is emerging that neonatal IH initiates epigenetic mechanisms involving DNA hypermethylation contributing to long-lasting increase in ROS levels. Since adult human subjects born preterm exhibit higher incidence of sleep-disordered breathing and hypertension, DNA hypomethylating agents might offer a novel therapeutic intervention to decrease long-term cardio-respiratory morbidity caused by neonatal IH.
Authors:
Jayasri Nanduri; Nanduri R Prabhakar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-27
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  185     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-07-22     Revised Date:  2014-01-26    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  105-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / physiology
Animals
Animals, Newborn
Carotid Body / physiology*
Chromaffin Cells / physiology*
Epigenesis, Genetic*
Fetal Hypoxia / genetics*
Humans
Infant, Newborn
Infant, Premature
Oxygen / blood*
Grant Support
ID/Acronym/Agency:
HL-76537/HL/NHLBI NIH HHS; HL-86493/HL/NHLBI NIH HHS; HL-90554/HL/NHLBI NIH HHS; R01 HL076537/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

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