Document Detail

Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations.
MedLine Citation:
PMID:  20955784     Owner:  NLM     Status:  MEDLINE    
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a ubiquitous environmental contaminant and known endocrine disruptor. Since humans and animals are most sensitive to toxicant exposure during development, we previously developed a mouse model of in utero TCDD exposure in order to examine the impact of this toxicant on adult reproductive function. Our initial in utero toxicant-exposure study revealed a dose-dependent reduction in uterine sensitivity to progesterone; however, we did not previously explore establishment or maintenance of pregnancy. Thus, in the current study, we examined pregnancy outcomes in adult C57BL/6 mice with a history of developmental TCDD exposure. Herein we demonstrate reduced fertility and an increased incidence of premature birth (PTB) in F1 mice exposed in utero to TCDD as well as in three subsequent generations. Finally, our studies revealed that mice with a history of developmental TCDD exposure exhibit an increased sensitivity to inflammation which further negatively impacted gestation length in all generations examined.
Kaylon L Bruner-Tran; Kevin G Osteen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-16
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  31     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-07-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Women's Reproductive Health Research Center, Department of Obstetrics & Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
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MeSH Terms
Disease Models, Animal
Dose-Response Relationship, Drug
Environmental Pollutants / toxicity*
Epigenesis, Genetic / drug effects*
Fertility / drug effects*,  genetics
Maternal Exposure
Mice, Inbred C57BL
Premature Birth / chemically induced
Prenatal Exposure Delayed Effects / chemically induced*,  genetics
Tetrachlorodibenzodioxin / toxicity*
Uterus / drug effects,  pathology
Grant Support
Reg. No./Substance:
0/Environmental Pollutants; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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