| Developmental Exposure to Di(2-ethylhexyl) Phthalate Impairs Endocrine Pancreas and Leads to Long-term Adverse Effects on Glucose Homeostasis in the Rat. | |
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MedLine Citation:
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PMID: 21673306 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Di-(2-ethylhexyl)-phthalate (DEHP), a typical endocrine disrupting chemical (EDC), is widely used as plasticizer. DEHP exposure in humans is virtually ubiquitous, and those undergoing certain medical procedures can be especially high. In this study, we investigated whether developmental DEHP exposure disrupted glucose homeostasis in the rat and whether this was associated with the early impairment in endocrine pancreas. Pregnant Wistar rats were administered DEHP (1.25 and 6.25 mg/kg/day) or corn oil throughout gestation and lactation by oral gavage. Body weight, glucose and insulin tolerance, beta cells morphometry and function were examined in offspring during the growth. In this study, developmental DEHP exposure led to abnormal beta cells ultrastructure, reduced beta cells mass and pancreatic insulin content, as well as alterations in the expression of genes involving in pancreas development and beta cells function in offspring at weaning. At adulthood, female DEHP-exposed offspring exhibited elevated blood glucose, reduced serum insulin, impaired glucose tolerance and insulin secretion. Male DEHP-exposed offspring had increased serum insulin, although there were no significant differences in blood glucose at fasting and during glucose tolerance test. In addition, both male and female DEHP-exposed offspring had significantly lower birth weight and maintained relatively lower body weight up to 27 weeks of age. These results suggest that developmental exposure to DEHP gives rise to beta cells dysfunction and the whole-body glucometabolic abnormalities in the rat. DEHP exposure in critical period of development can be a potential risk factor, at least in part, for developing diabetes. |
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Authors:
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Yi Lin; Jie Wei; Yuanyuan Li; Jun Chen; Zhao Zhou; Liqiong Song; Zhengzheng Wei; Ziquan Lv; Xi Chen; Wei Xia; Shunqing Xu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-14 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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